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pancreatic islet preparations for insulin secretion analyses Cellular and Molecular Studies Cryo-electron microscopy structural determinations of receptor-peptide complexes G-protein coupling and cAMP signaling assays Gastric emptying studies in both animal models and human subjects Research Limitations & Regulatory Status Critical Gaps in Current Evidence Despite promising phase 2 clinical trial results, GLP3 faces substantial evidence gaps that require resolution before widespread clinical application becomes possible
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Baseline and periodic measurement of vitamins A, D, E, and K may be warranted in patients with documented malabsorption
10.1083/jcb.201005160 88 PartridgeL.DeelenJ.SlagboomP
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