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While tirzepatide has yet to demonstrate direct cardiovascular risk outcomes in patients without type 2 diabetes, tirzepatide-treated groups did demonstrate reductions in cardiometabolic variables resulting in a significantly lower 10-year predicted ASCVD risk in patients with overweight or obesity without type 2 diabetes in post hoc analysis of the SURMOUNT-1 trial [49]

Any laboratory animal research involving 5-Amino-1MQ should be conducted under approved institutional protocols and should follow applicable animal-care and reporting standards, including the Guide for the Care and Use of Laboratory Animals and transparent reporting principles such as ARRIVE 2.0 where relevant

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