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Sensitivity Analyses A probabilistic sensitivity analysis (PSA) was performed using a second-order Monte Carlo approach, with sampling around the base case clinical inputs based on the standard errors of the proportions of patients achieving targets collected in the PIONEER 2, 3, and 4 trials (Table 1)

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Although no clinical trial has yet evaluated the effect of glitazone therapy on skeletal muscle mass or strength in humans as a standalone therapy, pioglitazone has been tested as an adjunctive therapy in older people with impaired physical function undergoing a weight loss programme

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They can be different sizes and often appear on the gums or cheek

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