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Source: Jastreboff et al., NEJM 2023 TRIUMPH-4 Phase 3 (68 weeks, 445 participants) Phase 2 Type 2 Diabetes Trial (36 weeks, 281 participants) In the type 2 diabetes population, weight loss was lower than in the obesity trial which is consistent with the pattern seen across all GLP-1 drugs
This clean endocrine profile is the peptide's primary safety advantage over full HGH therapy or GH secretagogues
However, at the 24-week mark, the magnitude of weight loss efficacy does not appear to be negatively affected by the lower baseline, including for Semaglutide and Tirzepatide
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