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HER2 overexpression or pathway activation is exhibited in about 5% to 20% of CCAs, and 15% to 30% of gallbladder cancer, for which off-label fam-trastuzumab deruxtecan-nxki (Enhertu, for IHC 3+), trastuzumab/pertuzumab (Phesgo) and trastuzumab + tucatinib (Herceptin + Tukysa) are recommended for HER2+ tumors after disease progression

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doi: 10.1016/S0021-9258(18)67324-7 25 NianMDruckerDJIrwinD

In a meta-analysis of cohort studies that reported on outcomes of GLP-1 RAs in adult kidney transplant recipients, no significant changes in eGFR (95% CI 0.64-0.50