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Eli Lilly's May 21, 2026 announcement reported mean body-weight reduction of 19.0% on 4 mg, 25.9% on 9 mg, and 28.3% on 12 mg, compared with 2.2% on placebo [1][2]
Nevertheless, the belief that carnitine is a slimming agent has been negated in the middle of 90s [20]
The evidence supporting this view: Patients who develop heartburn on GLP-1 medications and manage it with behavioral changes alone lose more weight than patients who immediately start PPIs (retrospective analysis, Kochar et al., Obesity 2024)
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