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If a patient experiences side effects, the dose escalation is delayed
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Obesity itself drives chronic inflammation through adipose tissue dysfunction and increased production of inflammatory mediators
During induced ischemia in experimental models, GLP-1 was in fact able to prompt an increase in anaerobic glycolysis in the ischemic regions, to counteract the lack of oxygen supply as demonstrated using a 1- 13 C glucose clamp combined with MRS-based isotope analysis [150]
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