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Following ischemic-induced abnormal opening of the mitochondrial permeability transition pore (mPTP), mtDNA is released into the cytoplasm, where it can be recognized by the pattern recognition receptor TLR9, thereby activating the production of type I interferons and the STING signaling pathway, and driving a distinct interferon-associated neuroinflammatory response (130)

Contrary to our hypothesis, we found no significant differences in Glu or GABA levels, nor in the Glu/GABA ratio, between the ASD and control groups