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Thereby, an upregulation of CD68 occurs and initiates a signaling cascade, which might be implicated in the pathogenesis of arthritis, and may be relevant for other inflammatory diseases as well ( Another well-known interaction of DPP4 is with extracellular matrix proteins like collagen and fibronectin ( Potential Receptors for sDPP4 Since DPP4 is shedded from the membrane of cells with intact enzymatic and cysteine-rich region, it can also exert biological functions in a paracrine or endocrine manner

Harpreet Tsui, DO, an internal medicine and obesity specialist, explained, We know that abdominal fat releases pro-inflammatory adipokines, increasing systemic inflammation that can trigger or worsen autoimmune diseases

Repeated injections in the same area can also cause localized tissue thickening or irritation

Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells