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This could also have detrimental effects on FA buffering capacity in E4s
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Most importantly, it facilitates the transport of long-chain fatty acids into the mitochondria for use in ATP production
On a molecular basis, the TRPA1 (Transient receptor potential ankyrin subtype 1) ion channels in nociceptors allow the release of calcitonin gene-related peptide (CGRP) from dural afferents upon activation, mediating neurogenic inflammation, and migraine behavioral picture in animal models (25)
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