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For chromatographic metabolite separation, a Vanquish ultra-performance liquid chromatography (UPLC) system was coupled to a Q Exactive HF (QE-HF) mass spectrometer equipped with heated electrospray ionization (HESI

Marginal structural models were used to evaluate the association between GLP-1RAs and MACE risk, accounting for time-varying confounding using inverse probability weighting, although residual confounding cannot be fully excluded

Knowing this arc prevents discouragement during the slow early weeks and sets appropriate expectations for when the most dramatic changes will appear