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Within the set of tested PROTACs, a trend towards reduced effects on cell viability was observed for PROTACs carrying an amide group connecting the CCW16 ligand and the chemical linker moiety, which was introduced for synthetic reasons, compared to the derivatives and CCW16 lacking an amide bond at this position
Additionally, the cellular metabolism of tumor cells varies considerably among breast cancer subtypes, due to their highly heterogeneous nature (5)
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