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Shortage of vitamin B12 can also result in pernicious anemia, which may be due to impaired absorption of vitamin B12 caused by a lack of intrinsic factora substance necessary for the absorption of vitamin B12 in the intestines
MTHFR mutations affect folate metabolism and can impact methylation pathways including B12 activation
More serious deficiencies have the potential to impair heart and neurological function, leading to a wide range of serious symptoms, including but not limited to tinnitus, severe joint pain, memory problems, depression, anxiety, poor muscle function, ataxia and changes in reflexes
Mood : anxiety, depression sometimes to the point of suicidality
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