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Caution is advised in patients with a history of pancreatitis, and these medications should be avoided during pregnancy or discontinued well before planned conception (e.g., 2 months before planned pregnancy for semaglutide based on its half-life)
The present LCMS/MS assay and the pharmacokinetic results may be helpful to understand better the effect of liraglutide in the brain for further preclinical and clinical studies of liraglutide
If severe, stop use and consult a healthcare professional
These findings support bispecific GLP-1/GLP-2 agonism as a mechanistically distinct incretin strategy in advanced T2D
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