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[1] Contamination risks, potency variations, and sterility concerns represent significant potential hazards with compounded injectable medications
On the cardiovascular side, the SUSTAIN-6 trial in 2016 was one of the first to report a significant reduction in major adverse cardiovascular events with semaglutide in adults with type 2 diabetes and high cardiovascular risk (Marso et al., NEJM, 2016)
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Subgroup analyses were available for PIONEER 3 and 4, which generally showed consistent treatment effects by background therapy for A1C or body weight (metformin with or without SU in PIONEER 3, metformin with or without SGLT2 inhibitor in PIONEER 4)
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